Which of the following statements doesn’t hold true for blood clotting cascade? i. Ruptured platelets release thromboplastin. ii. Prothrombinis converted into thrombin in the presence of vitamin K and Na+ions. iii. Fibrinogen is converted into fibrin through enzymatic action of thrombin in the presence of Ca++ions iv. Fibrin makes clot via process of polymerisation.
Prothrombin plays crucial role in blood coagulation and vitamin K is considered essential for blood clotting, now read the following : i. Vitamin K is necessary for synthesis of prothrombin in liver. ii. Vitamin K is necessary for synthesis of prothrombin in bone marrow. iii. Vitamin K is necessary for conversion of prothrombin into active thrombin.